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Harinath Chakrapani Selected Research

diazeniumdiolate

6/2013INDQ/NO, a bioreductively activated nitric oxide prodrug.
2/2011The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species.
11/2008Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs.
11/2008Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.

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Harinath Chakrapani Research Topics

Disease

12Neoplasms (Cancer)
12/2017 - 03/2008
3Infections
01/2019 - 07/2015
3Leukemia
05/2009 - 03/2008
2Neuroinflammatory Diseases
10/2021 - 01/2021
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2011 - 02/2011
1Staphylococcal Infections
07/2014
1Tuberculosis (Tuberculoses)
06/2012
1Adenocarcinoma of Lung
02/2011
1Lung Neoplasms (Lung Cancer)
02/2011
1Schistosomiasis (Bilharziasis)
10/2009

Drug/Important Bio-Agent (IBA)

9Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2014 - 03/2008
8ProdrugsIBA
11/2013 - 03/2008
5Glutathione (Reduced Glutathione)IBA
11/2011 - 03/2008
4Pharmaceutical PreparationsIBA
07/2015 - 06/2012
4diazeniumdiolateIBA
06/2013 - 11/2008
3EnzymesIBA
10/2021 - 06/2013
2Proteins (Proteins, Gene)FDA Link
02/2011 - 12/2008
2O(2)- (2,4- dinitro- 5- (N- methyl- N- 4- carboxyphenylamino)phenyl 1- N,N- dimethylamino)diazen- 1- ium- 1,2- diolateIBA
12/2008 - 03/2008
1persulfidesIBA
10/2021
1Toll-Like Receptor 2IBA
01/2021
1Anti-Bacterial Agents (Antibiotics)IBA
01/2019
1FluoroquinolonesIBA
01/2019
1BuffersIBA
11/2013
1NitroreductasesIBA
11/2013
1NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)IBA
06/2013
1DNA (Deoxyribonucleic Acid)IBA
06/2012
1Sulfhydryl Compounds (Thiols)IBA
06/2012
1Cytotoxins (Cytolysins)IBA
02/2011
1Biomarkers (Surrogate Marker)IBA
02/2011
1Reactive Oxygen Species (Oxygen Radicals)IBA
02/2011
1Reactive Nitrogen SpeciesIBA
02/2011
1Cytochromes c (Cytochrome c)IBA
02/2011
1PiperazineIBA
05/2009
1Carboxylic AcidsIBA
11/2008
1Glutathione Transferase (Glutathione S-Transferase)IBA
11/2008
1AnionsIBA
11/2008
1Biological ProductsIBA
11/2008

Therapy/Procedure

4Therapeutics
01/2019 - 02/2011
1Precision Medicine
12/2017